蕈样肉芽肿免疫表型分析及分子遗传学研究进展

Immunophenotypic characterization and molecular genetic advances in mycosis fungoides

蕈样肉芽肿(MF)是最常见的原发皮肤T细胞淋巴瘤,临床上病程缓慢、迁延。MF肿瘤性T细胞最常见的免疫表型是α/βT辅助细胞表型(βF1+、TCR-γ-、CD3+、CD4+、CD5+、CD8-、CD45Ro+、TIA-1-),占80%左右。但仍有一部分MF免疫表型很少见,如表达细胞毒性T细胞的标记(CD8+,TIA-1+)、表达B细胞的标记(CD20+)、表达间变大细胞的标记(CD30+)等,这些少见的免疫表型很容易与其它侵袭性较高的淋巴瘤相混淆,造成误诊、误治。本文对MF的免疫表型进行分析总结,并探讨其分子遗传学研究进展。

Mycosis fungoides(MF)is the most common primary cutaneous T-cell lymphoma,which is characterized by slow evolution and protracted course.The most common immunophenotype of MF isα/βT helper cell(βF1+,TCR-γ-,CD3+,CD4+,CD5+,CD8-,CD45RO+,TIA-1-),accounting for 80%.However,there are still rare and special immunophenotypes:expression of cytotoxic markers of T cells(CD8+,TIA-1+),expression of B-cell marker(CD20+),and expression of anaplastic large cell marker(CD30+).These rare immunophenotypes are easily confused with other aggressive lymphomas,resulting in misdiagnosis and mistreatment.In this review paper,the immunophenotype of MF was summarized,and the research advances of molecular genetics were discussed.