血管紧张素转换酶抑制剂联合钙离子拮抗剂治疗原发性高血压患者的疗效分析

Effect Analysis of Angiotensin Converting Enzyme Inhibitor Combined with Calcium Antagonist in the Treatment of Patients with Essential Hypertension

目的探讨血管紧张素转换酶抑制剂(ACEI)类联合钙离子拮抗剂(CCB)类降压药治疗原发性高血压患者的临床疗效,分析对病人晨峰血压(MBPS)和血压变异性(BPV)影响。方法选择2017年6月~2019年12月德兴市人民医院收治的原发性高血压病人80例,按照随机数字表法分为对照组和观察组各40例。观察组使用ACEI联合CCB类降压药治疗,对照组仅使用CCB类降压药治疗,分别在治疗前及治疗2个月后进行动态血压监测,观察两组治疗前后MBPS和BPV的变化。结果治疗后,两组的24h平均收缩压(24h SBP)、24h平均舒张压(24h DBP)较治疗前均降低,且观察组低于对照组,差异均有统计学意义(P<0.05);两组24h平均收缩压变异性(24h SBPV)、24h平均舒张压变异性(24h DBPV)、MBPS较治疗前均降低,且观察组低于对照组,差异均有统计学意义(P<0.05);治疗后,两组MBPS(+)所占比降低,且观察组低于对照组,MBPS(-)所占比升高,且观察组高于对照组,差异有统计学意义(P<0.05)。结论通过ACEI联合CCB类降压药可改善原发性高血压病人血压变异性和晨峰血压变化。

Objective To investigate the clinical efficacy of angiotensin converting enzyme inhibitors(ACEI)combined with calcium channel blockers(CCB)in the treatment of patients with essential hypertension,and to analyze the effect on the morning blood pressure(MBPS)and blood pressure variability(BPV)of patients.Methods 80 patients with essential hypertension admitted toDexing People's Hospital from June 2017 to December 2019 were selected.According to the random number table method,they were divided into control group and observation group,40 cases each.The observation group was treated with ACEI combined with CCB class antihypertensive drugs,while the control group was treated with CCB class antihypertensive drugs only.The ambulatory blood pressure monitoring was performed before and 2 months after treatment,respectively,to observe the changes of MBPS and BPV before and after treatment in the two groups.Results After treatment,the 24h mean systolic blood pressure(24h SBP)and 24h mean diastolic blood pressure(24h DBP)of the two groups were both lower than those before treatment,and the observation group was lower than the control group,with statistical significant differences(P<0.05).The 24h mean systolic blood pressure variability(24h SBPV),24h mean diastolic blood pressure variability(24h DBPV)and MBPS in the two groups were all lower than that before treatment,and the observation group was lower than the control group,with statistical significant differences(P<0.05).After treatment,the proportion of MBPS(+)in the two groups decreased,and the observation group was lower than the control group.the proportion of MBPS(-)was increased,and the observation group was higher than the control group,the difference was statistically significant(P<0.05).Conclusion ACEI combined with CCB can improve the blood pressure variability and morning peak blood pressure changesin patients with essential hypertension.