基于MRI评估的胰腺脂肪沉积及腹部脂肪分布与原发性高血压的相关性研究

Correlation between pancreatic fat deposition and abdominal fat distribution and essential hypertension based on MRI

目的探讨基于MRI评估的胰腺脂肪沉积、内脏脂肪和皮下脂肪与原发性高血压的相关性。材料与方法纳入54例高血压患者和108例对照者。应用半自动分割对全胰腺进行分割,并测量全胰腺脂肪分数值。应用Image J软件测量内脏脂肪(visceral adipose tissue,VAT)和皮下脂肪(subcutaneous adipose tissue,SAT)面积,并记录VAT和SAT脂肪分数值(fat fraction,FF),计算内脏/皮下脂肪组织的面积比(V/S)。数据由SPSS进行统计学分析。P<0.05被认为差异具有统计学意义。结果高血压患者全胰腺脂肪分数值、VAT和SAT面积、V/S、VAT和SAT脂肪分数值均高于对照者。全胰腺脂肪分数值对高血压的诊断价值最高(AUC=0.816)。全胰腺脂肪分数的阈值为10.15%,对高血压诊断的敏感度为75.9%,特异度为81.5%。全胰腺FF与VAT面积和脂肪分数值呈中等相关性(r=0.541、0.561);与SAT面积、脂肪分数值和V/S的相关性较低(r=0.280、0.324、0.266)。结论高血压者与全胰腺脂肪分数、VAT和SAT增多有关。全胰腺脂肪分数与VAT和SAT的增加相关。

Objective:To investigate the association of pancreatic fat with visceral adipose tissue(VAT)and subcutaneous adipose tissue(SAT),and hypertension.Materials and Methods:A total of 54 patients with hypertension and 108 control subjects who underwent an upper abdomen MRI scan with IDEAL-IQ sequence were included.Pancreatic tissue was segmented and whole pancreatic fat fraction(FF)were measured.VAT and SAT area were measured.VAT and SAT FF were recorded.Visceral/subcutaneous adipose tissue area ratio(V/S)was also calculated.Results:Patients with hypertension had higher whole pancreatic FF,VAT area,SAT area,V/S,VAT FF and SAT FF.Whole pancreatic FF has the highest diagnostic value in detecting hypertension(area under the curve,0.816).The threshold of whole pancreatic FF of 10.15%showed a sensitivity of 75.9%and specificity of 81.5%for hypertension.Whole pancreatic FF showed a moderate correlation with VAT area(r=0.541)and VAT FF(r=0.561)and a weak correlation with SAT area(r=0.280),SAT FF(r=0.324)and V/S(r=0.266).Conclusions:Hypertension is associated with higher whole pancreatic FF,VAT and SAT.Both increased area and FF of VAT and SAT are positively correlated with whole pancreatic FF.