基于亚胺瞬态导向策略的过渡金属催化的碳氢键活化

Transition Metal-Catalyzed C-H Activation via Imine-Based Transient Directing Group Strategy

在过去几十年,过渡金属催化的碳氢键活化取得了巨大的发展,并给有机合成领域带来了革命性的改变.与传统的通过共价连接的导向基相比,基于瞬态导向策略的碳氢键活化,因为规避了传统导向基需要额外的步骤进行安装和脱除的不足,极大地提高了合成效率,拓宽了合成应用范围.综述了近年来基于亚胺瞬态导向策略的过渡金属催化的碳氢键活化的研究进展,着重探讨了各种瞬态导向基及其应用.按照底物类型和所活化碳氢键的类型进行分类,并对该领域目前存在的局限性和未来发展进行了总结和展望.

In the past decades,transition metal-catalyzed C—H activation has experienced tremendous growth and revolutionized the field of organic synthesis.Several elegant strategies have been developed to promote reactivity and control precise site-selectivity.Among which,transient directing group strategy has been recognized to be an efficient and powerful approach for selective C—H functionalization.In contrast to traditional directing groups with covalent linkage,transient directing group strategy circumvents the covalent installation and removal of directing groups,which significantly improve the synthetic efficiency and broaden the range of synthetic applications.The recent advances in imine-based transition directing groups are summarized,providing an overview of recent achievements in this cutting-edge research field over the past few years.For clarity,it is classified into two sections according to the type of substrate and the type of activated hydrocarbon bond.Emphasis is placed on the fully discussion of various transient directing groups and their applications.Finally,the limitations of previous works and perspectives on this cutting-edge area are also described.