多电荷环糊精的超分子组装

Supramolecular Assemblies of Multi-Charged Cyclodextrins

多电荷环糊精作为一类具有优异的水溶性、低生物毒性和高电荷密度的大环主体,可与有机、无机和生物分子通过疏水的空腔和静电相互作用等多种协同作用力构筑具有稳定拓扑形貌、功能多样性和刺激响应性的智能超分子组装体而被广泛研究.综述了近年来以正/负电荷及两亲性多电荷环糊精作为主体构筑的具有pH、光、酶、氧化还原、磁和多重刺激响应的智能超分子组装体以及其在药物传递、控制释放和传感检测等领域应用的最新研究进展,并对多电荷环糊精智能超分子组装体所面临的挑战和未来的发展进行了探讨.

As a class of macrocyclic host with excellent water solubility,low biotoxicity and high charge density,multicharged cyclodextrins have been extensively studied because they can interact with organic/inorganic/biological molecules through multiple synergistic forces such as the hydrophobic cavities and electrostatic interactions to construct the smart supramolecular assemblies with stable topology,functional diversity and stimulus responsiveness.The latest research progress of pH-,photo-,enzyme-,redox-,magnetic-and multi-stimulus responsive smart supramolecular assemblies,which are constructed by typical positively/negatively charged and amphiphilic multi-charged cyclodextrins including their application in the fields of drug delivery,controlled release and sensory detection is introduced,and the challenges and future developments of multi-charged cyclodextrin smart supramolecular assemblies are discussed.