基于文献分析的IgA肾病患者共生菌群特征

Analysis of characteristics of symbiotic flora in patients with IgA nephropathy based on literature analysis

目的分析IgA肾病(IgA nephropathy,IgAN)患者的口腔菌群和肠道菌群特征。方法在数据库Pubmed、Web of science、Cochrane Library、CNKI检索调查IgAN患者共生菌群特征的文献,对文献结果进行系统归纳和分析。结果限于菌群鉴定方法的代际差异和文献报告的不全面性,文献结果异质性较大;IgAN患者和复发性扁桃体炎患者的扁桃体菌群结构相似;IgAN患者与健康人群的唾液菌群结构存在差异;牙周炎合并或不合并IgAN的患者牙龈菌斑菌群结构存在差异。与健康对照比较,IgAN患者肠道菌群丰度降低,菌群结构发生变化。结论IgAN患者口腔菌群和肠道菌群的丰度和结构可能发生改变,需要采用先进测序技术且大样本量的研究来进一步揭示IgAN患者口腔菌群和肠道菌群的具体特征。

Objective To analyze the characteristics of oral and intestinal microbiota of IgA nephropathy(IgAN)patients.Methods Literature investigating the characteristics of symbiotic flora in IgAN patients were searched in Pubmed,Web of science,Cochrane Library and CNKI,and the results were systematically summarized and analyzed.Results With limitation of the intergenerational difference of methods for bacterial identification and the incompleteness of literature reports,there were big difference among results of the included studies.The structure of tonsillar flora in patients with IgAN was similar to that in patients with recurrent tonsillitis;the structure of salivary flora in IgAN patients was distinct from that in healthy people;the structure of gingival plaque flora was different among patients with periodontitis with or without IgAN.Compared with the healthy control,the intestinal microbiota abundance in IgAN patients was reduced the flora structure changed.Conclusions The abundance and composition of oral and intestinal microbiota in IgAN patients may be altered,and more specific changes require larger studies using advanced sequencing techniques and studies of bigger sample size are required for further clarification of detailed features of oral and intestinal microbiota in IgAN patients.