心外膜脂肪组织对慢性肾脏病的影响

Effect of epicardial adipose tissue on chronic kidney disease

在生理条件下,心外膜脂肪组织能分泌具有心脏保护特性的脂肪因子。病理状态下,其分泌的生物活性分子会促进动脉粥样硬化、心肌纤维化,从而引发心血管疾病。慢性肾脏病患者的心血管疾病发病率和病死率都很高,研究表明其心外膜脂肪组织与心血管疾病的发生息息相关。因此,了解心外膜脂肪组织与慢性肾脏病的联系具有重要的临床意义。

Under physiological conditions,epicardial adipose tissue can secrete adipokines with cardioprotective properties.Under pathological conditions,the biologically active molecules secreted by it will promote atherosclerosis and myocardial fibrosis,thus triggering cardiovascular disease.The morbidity and mortality of cardiovascular disease in patients with chronic kidney disease are very high.Studies have shown that the epicardial fatty tissue is closely related to the occurrence of cardiovascular disease.Therefore,it is of great clinical significance to understand the relationship between epicardial adipose tissue and chronic kidney disease.