平均血小板体积/淋巴细胞比值与冠心病经皮冠状动脉介入治疗术后长期死亡率的关系:一项队列研究

Association of mean platelet volume to lymphocyte ratio with long⁃term mortality after PCI in coronary heart disease:a cohort study

目的探究血小板体积与淋巴细胞比值(MPVLR)与冠心病经皮冠状动脉介入(PCI)术后患者长期死亡率的相关性。方法筛选2013年1月至2017年12月就诊于郑州大学第一附属医院心内科行PCI术的冠心病患者3472例,根据ROC曲线确定MPVLR预测冠心病PCI术后患者长期死亡率的最佳临界值为5.69,根据临界值水平将分为低MPVLR组(MPVLR<5.69,n=2433)和高MPVLR组(MPVLR≥5.69,n=1039)。结果单因素分析显示两组间全因死亡及心源性死亡在两组之间有统计学差异(P<0.05);Cox多因素回归分析显示:入院时高MPVLR是冠心病患者PCI术后长期心源性死亡(HR=1.630,95%CI:1.020~2.640,P<0.05)及全因死亡(HR=1.579,95%CI:1.093~2.281,P<0.05)的独立危险因素。结论高MPVLR对于冠心病患者PCI术后长期死亡事件有一定预测价值。

Objective To investigate the association of mean platelet volume to lymphocyte ratio(MPVLR)with long⁃term mortality in patients with coronary heart disease after percutaneous coronary intervention(PCI).Methods From January 2013 to December 2017,3472 patients with coronary heart disease undergoing PCI in our hospital were enrolled.Based on receiver operating characteristics curve analysis,the best threshold value for predicting long⁃term mortality in patients with coronary heart disease after PCI was 5.69.According to the threshold value,the patients were divided into the low MPVLR(MPVLR<5.69,n=2433)and the high MPVLR group(MPVLR≥5.69,n=1039).Results Inunivariate analysis,there was a significant difference in all⁃cause death and cardiogenic death between the two groups(P<0.05);Cox multivariate regression analysis showed that higher MPVLR level in admission was an independent risk factor for long⁃term cardiogenic death(HR=1.630,95%CI:1.020~2.640,P<0.05)and all⁃cause death(HR=1.579,95%CI:1.093~2.281,P<0.05)in patients with coronary heart disease after PCI.Conclusions MPVLR has certain predictive value for long⁃term death events in patients with coronary heart disease after PCI.