病理性瘢痕相关炎性因素的研究

Study on Inflammatory Factors Related to Pathological Scars

病理性瘢痕是一种真皮纤维化病变,主要包括增生性瘢痕和瘢痕疙瘩,临床特征为炎性细胞增殖、成纤维细胞数量增加、新生血管和胶原蛋白沉积。目前关于病理性瘢痕的发病机理尚未完全阐明,其研究一直是皮肤科、美容及外科修复领域研究的难点与热点。而炎性因素与病理性瘢痕的形成过程密不可分,其中环氧合酶、肿瘤坏死因子、白细胞介素、巨噬细胞及淋巴细胞等参与病理性瘢痕形成。本文就以上炎症介质及炎症细胞与病理性瘢痕形成的关系作一综述,以期为其临床治疗提供参考。

Pathological scars are a kind of dermal fibrotic lesions,which mainly include hypertrophic scars and keloids.It is characterized by inflammatory cell proliferation,increased fibroblast numbers,neovascularization and collagen deposition.However,its pathogenesis has not been fully elucidated,and its research has always been a difficult and hot spot in the fields of dermatology,cosmetology and surgical repair.Inflammatory factors are inseparable from the formation process of pathological scars.Inflammatory factors involved in the formation of pathological scars include cyclooxygenase,tumor necrosis factor,interleukin,macrophages and lymphocytes.This article reviews the relationship between the above inflammatory mediators,inflammatory cells and pathological scar formation,in order to provide references for its clinical treatment.