活性氧对胚胎发育的影响

The Effect of Reactive Oxygen Species on Embryonic Development

活性氧(ROS)是胚胎发育过程中产生的一种氧自由基,包括O2、H2O2、O2-、-OH等。正常含量的ROS会对胚胎发育起保护作用,而过量的ROS则会使得胚胎发育受到阻滞,其通过影响不同的因子(如p53因子、细胞自噬、精子质量等)对胚胎产生作用。本文就ROS对胚胎的影响机制及减轻ROS对胚胎损伤的方法作一综述,以期为胚胎学等研究提供理论依据。

Reactive oxygen species(ROS)are oxygen free radicals produced during embryonic development,including O2,H2O2,O2-,-OH,etc.The normal content of ROS will protect the embryo development,while excessive ROS will block the embryo development,which affects the embryo by affecting different factors(such as p53 factor,autophagy,sperm quality,etc.).This article reviews the mechanism of ROS on embryos and the methods to reduce the damage of ROS on embryos,hoping to provide a theoretical basis for embryology and other research.