扫频光相干断层扫描对不同屈光度近视患者脉络膜厚度分析

Analysis of Choroidal Thickness in Myopia Patients with Different Diopter by Swept Optical Coherence Tomography

目的通过比较不同屈光度近视患者脉络膜厚度,初步探讨近视发生发展的可能机制。方法收集2020年1月~8月在达州市中心医院眼科准分子激光中心行近视术前检查的患者共82例,根据等效球镜分别分为低度近视组(-0.50D~-3.00D)、中度近视组(-3.00D~-6.00D),高度近视组(≥-6.00D),使用视微影像超广角扫频相干光断层扫描(SS-OCTA)测量82例近视患者以黄斑中心凹为圆心直径分别为1、3、6、9、12 mm圆形的上方(S)颞侧(T)、下方(I)、鼻侧(N)脉络膜厚度(CT),取右眼进行统计学分析。结果随近视度数增加,低、中、高度近视患者CT变薄,差异有统计数意义(P<0.05);不同近视组鼻侧CT最薄,且三组进行比较,鼻侧CT最先出现改变,下方次之。三组进行两两比较,高度近视组CT与低度近视组、中度近视组比较,差异有统计学意义(P<0.05),而低度近视组与中度近视组比较,差异无统计学意义(P>0.05)。结论随着近视度数的增加CT变薄,近视患者CT变薄方位具有不一致性,与正常CT分布规律不同,与近视相关的一些列并发症可能与变薄的部位有一定联系,提示脉络膜的改变可能参与近视的发生发展。

Objective By comparing the choroidal thickness of myopia patients with different diopter,to preliminarily explore the possible mechanism of the occurrence and development of myopia.Methods A total of 82 patients who underwent preoperative examinations for myopia at the Excimer Laser Center of the Department of Ophthalmology of Dazhou Central Hospital from January to August 2020 were collected.According to the equivalent spherical lens,they are divided into low myopia group(-0.50D~-3.00D),moderate myopia group(-3.00D~-6.00D),high myopia group(≥-6.00D),using microscopic imaging ultra-wide-angle swept coherent optical tomography(SS-OCTA)to measure 82 myopia patients with the macular fovea as the center of the circle with diameters of 1,3,6,9,12 mm above the circle(S),temporal side(T),lower(I),and nasal(N)choroidal thickness(CT),take the right eye for statistical analysis.Results As the degree of myopia increases,the CT thinning of patients with low,medium,and high myopia was statistically significant(P<0.05);the nasal CT of the different myopia groups was the thinnest,and when the three groups are compared,the nasal CT was the first to change.Followed below.The three groups were compared in pairs.There was a statistically significant difference between CT of the high myopia group and the low myopia group and the moderate myopia group(P<0.05),However,there was no significant difference between the low myopia group and the moderate myopia group(P>0.05).Conclusion With the increase of myopia power,CT thinning is inconsistent in the direction of CT thinning in myopia patients,which is different from the normal CT distribution.A series of complications related to myopia may be related to the thinning site to some extent,suggesting choroidal changes May be involved in the occurrence and development of myopia.