温阳健脾汤治疗慢性萎缩性胃炎癌前病变的疗效及安全性

Efficacy and Safety of Wenyang Jianpi Soup in the Treatment of CAG-PLGC

目的通过观察温阳健脾汤对慢性萎缩性胃炎癌前病变患者的病理疗效及用药安全性,以期为中医药临床诊治此类疾病提供依据。方法收集2018年1月~2019年3月在我院进行中医汤药治疗的慢性萎缩性胃炎癌前病变患者48例,给予温阳健脾汤治疗12周,比较治疗前后中医证候总积分、病理组织学积分、中医证候疗效、病理疗效进行评价,并对用药安全性进行评估。结果治疗后中医证候总积分、病理各组积分均较治疗前下降,差异有统计学意义(P<0.05)。中医证候疗效总有效率为83.33%,病理疗效总有效率为89.58%,且治疗后均未发生严重药物不良反应。结论温阳健脾汤对胃癌前病变患者的临床症状及病理组织学改变均有良好的改善作用,效果显著,且用药安全可靠。

Objective To observe the pathological efficacy and drug safety of Wenyang Jianpi soup on patients with precancerous lesions of chronic atrophic gastritis,in order to provide a basis for the clinical diagnosis and treatment of such diseases in traditional Chinese medicine.Methods A collection of 48 patients with precancerous lesions of chronic atrophic gastritis who were treated with TCM decoctions in our hospital from January 2018 to March 2019 were treated with Wenyang Jianpi soup for 12 weeks.The total scores of TCM syndromes and histopathology were compared before and after treatment.Score,evaluate the curative effect of TCM syndrome,pathological curative effect,and evaluate the safety of medication.Results After treatment,the total score of TCM syndromes and the scores of each pathology group decreased compared with that before treatment,the difference was statistically significant(P<0.05).The total effective rate of TCM syndrome curative effect was 83.33%,the total effective rate of pathological curative effect was 89.58%,and no serious adverse drug reactions occurred after treatment.Conclusion Wenyang Jianpi soup has a good effect on improving the clinical symptoms and histopathological changes of patients with gastric precancerous lesions,the effect is significant,and the medication is safe and reliable.