整体认知评估量表和事件相关电位在帕金森病认知损害诊断中的应用

The Application of Global Cognitive Assessment Scale and Event-related Potentials in the Diagnosis of Parkinson’s Disease with Cognitive Impairment

认知损害是帕金森病(PD)常见且十分重要的非运动症状,包括轻度认知损害和痴呆。PD认知损害发病率高,严重降低了PD患者的生活质量,增加了陪护者的压力。但PD认知损害起病隐匿,不易早期诊断。整体认知评估量表对认知损害敏感在临床中广泛应用。事件相关电位(ERP)是一种客观、无创进行大脑认知功能评估的神经电生理技术,在PD认知损害的诊断中显示出良好的相关性。整体认知评估量表可与ERP改变相结合对PD认知功能状态进行追踪观察,有助于早期对PD认知损害的识别和及时治疗。

Cognitive impairment is a common and very essential non-motor symptom of Parkinson’s disease(PD).It includes mild cognitive impairment and dementia.Its incidence is high,which severely reduces the quality of life of PD patients and increases the caregivers’pressure.As its hidden onset,it is not easy to diagnose early.The Global Cognitive Assessment Scale is sensitive to cognitive impairment and is widely used in clinical practice.The Event-related potentials(ERP)is an objective and non-invasive neuro-electrophysiological technique for evaluating cognitive function,and it shows good correlation in the diagnosis of PD with cognitive impairment(PD-CI).The Global Cognitive Assessment Scale can be combined with ERP changes to track and observe the cognitive function status of PD,which is helpful for early recognition and timely treatment.