通心络胶囊联合β-受体阻滞剂及其他抗心衰药物对老年高血压合并慢性心力衰竭患者心功能的影响

Effect of Tongxinluo capsule combined with β-blocker and other anti heart failure drugs on cardiac function in elderly patients with hypertension and chronic heart failure

目的探究通心络胶囊联合β-受体阻滞剂及其他抗心衰药物对老年高血压合并慢性心力衰竭患者心功能的影响。方法纳入2017年1月至2018年3月来本院就诊的高血压伴慢性心力衰竭老年患者共计90例,随机将其分为对照组和观察组,各45例。对照组患者给予硝苯地平+美托洛尔+贝那普利治疗,观察组患者在对照组基础上联合通心络胶囊治疗。比较两组患者的治疗效果、心脏功能及不良反应发生情况。结果观察组的治疗总有效率高于对照组(P<0.05)。治疗后,两组LVESD、LVEDD、BNP水平均降低,LVEF和6MWT均升高,且观察组优于对照组(P<0.05)。两组的恶心呕吐、头晕、皮疹及肝、肾功损害发生率比较,差异无统计学意义(P>0.05)。结论通心络胶囊联合β-受体阻滞剂及其他抗心衰药物应用于老年高血压伴慢性心力衰竭患者中,有利于提高治疗效果,改善心脏功能,值得临床推广和应用。

Objective To investigate the effect of Tongxinluo capsule combined withβ-blocker and other anti heart failure drugs on cardiac function in elderly patients with hypertension and chronic heart failure.Methods A total of 90 elderly patients with hypertension and chronic heart failure admitted in our hospital from January 2017 to March 2018 were included and randomly divided into control group and observation group,with 45 cases in each group.The control group was given nifedipine+metoprolol+benazepril treatment,and the observation group was combined with Tongxinluo capsule treatment on the basis of the control group.The treatment effect,cardiac function and reactions of the two groups were compared.Results The total effective rate of treatment of the observation group was higher than that of the control group(P<0.05).After treatment,the LVESD,LVEDD and BNP level in the two groups decreased,LVEF and 6MWT increased,and those in the observation group were better than the control group(P<0.05).There were no significant differences in the incidences of nausea and vomiting,dizziness,rash,liver and kidney function damage between the two groups(P>0.05).Conclusion Tongxinluo capsule combined withβ-blocker and other anti heart failure drugs applied in elderly patients with hypertension and chronic heart failure can improve the therapeutic effect and cardiac function,which is worthy of clinical promotion and application.