活性氧在糖尿病心肌病中的作用机制研究进展

Research progress on the mechanism of action of reactive oxygen species in diabetic cardiomyopathy

糖尿病心肌病是由糖尿病引起的葡萄糖及脂质代谢紊乱,这些代谢紊乱又可增强氧化应激,激活各种炎症途径,介导细胞及细胞外损伤,从而造成病理性心肌重构,进而导致心脏舒张及收缩功能障碍。尽管目前已提出了关于糖尿病心肌病的几种病理生理机制,但其确切发病机制仍不完全清楚。氧化应激为该病的主要机制之一,其中活性氧的生成增多是引起不良心肌重构的主要机制。因此,该文将针对糖尿病心肌病中活性氧的主要来源(NADPH氧化酶、线粒体、解偶联eNOS及黄嘌呤氧化酶)及其介导的心肌损害(脂质过氧化、蛋白质氧化及DNA损害)进行综述。

Diabetic cardiomyopathy(DCM)is an metabolic disorder of glucose and lipids caused by diabetes,which may strengthen oxidative stress,activate various inflammatory pathways,mediate cellular and extracellular damage,so as to induce pathological myocardial remodeling and lead to systolic and diastolic dysfunction.The exact pathogenesis of DCM remains unclear in spite of several pathophysiological mechanism of DCM have been put forward.Oxidative stress is one of the main causes of DCM,in which the increased production of reactive oxygen species(ROS)is the main mechanism causing adverse myocardial remodeling.So,the main source of ROS in DCM[Nadph oxidase,mitochondria,endothelial nitric oxide synthase(eNOS),xanthine oxidase,(XO)]and the ROS-mediated myocardial damage(lipid peroxidation,protein oxidation and DNA damage)are summarized in present paper.