影响多发性抽动症儿童临床预后的相关因素分析

Analysis of Related Factors Affecting the Clinical Prognosis of Children with Tourette's Syndrome

【目的】探讨影响多发性抽动症儿童临床预后的相关因素。【方法】选取2017年12月至2018年8月本院儿童保健科确诊为儿童多发性抽动症的75例患儿。随访1年,采取统一制订的问卷调查量表,采用单因素及多因素Logistic回归分析法分析影响患者预后的相关因素。【结果】好转与未愈患儿在精神疾病家族史、病情反复次数、病情严重程度评分、反复呼吸道感染次数等方面比较,差异有统计学意义(P<0.05)。Logistic回归分析显示,病情反复次数(OR=1.072,95%CI:1.030~1.116)、病情严重程度评分(OR=1.100,95%CI:1.025~1.181)、反复呼吸道感染(OR=1.279,95%CI:1.153~1.419)、精神疾病家族史(OR=0.182,95%CI:0.034~0.964)是影响多发性抽动症患儿预后的独立危险因素(P<0.05)。【结论】制约儿童多发性抽动症预后的因素较多如病情反复次数、病情严重程度、反复呼吸道感染等,充分掌握多发性抽动症的预后影响因素,且采取相关的预防方案可有效控制病情的复发。

【Objective】To explore the related factors affecting the clinical prognosis of children with multiple tourette syndrome.【Methods】From December 2017 to August 2018,75 children diagnosed with multiple tourette syndrome in the Department of Children Health of our hospital were selected.The patients were followed up for 1 year,a unified questionnaire survey scale was adopted,and univariate and multivariate Logistic regression analysis was used to analyze the related factors affecting the prognosis of the patients.【Results】There were statistically significant differences between the improved and uncured children in terms of family history of mental illness,number of repeated illness,severity score,and number of repeated respiratory tract infections(P<0.05).Logistic regression analysis showed that the number of recurrent cases(OR=1.072,95%CI:1.030~1.116),severity score(OR=1.100,95%CI:1.025~1.181),recurrent respiratory tract infection(OR=1.279,95%CI:1.153~1.419),and family history of mental illness(OR=0.182,95%CI:0.034~0.964)were independent risk factors affecting the prognosis of children with TIC(P<0.05).【Conclusion】There are many factors restricting the prognosis of Tourette's disease in children,such as the number of relapses,the severity of the disease,recurrent respiratory tract infection,etc.;fully mastering the prognostic factors of Tourette's disease and taking relevant preventive measures can effectively control the recurrence of the disease.