非小细胞肺癌患者术后肺部感染与PCT、sTREM-1及hs-CRP水平的关系

Relationship between Pulmonary Infection and PCT,sTREM-1 and hs-CRP Levels in Patients with NSCLC

【目的】探讨非小细胞肺癌(NSCLC)患者术后肺部感染与降钙素原(PCT)、髓样细胞触发受体(sTREM-1)及超敏C反应蛋白(hs-CRP)水平的关系。【方法】因NSCLC于本院行手术治疗并在术后出现肺部感染的37例患者设为肺部感染组,另外选择同期收治的37例术后未出现肺部感染的NSCLC患者为非肺部感染组。比较两组患者术后24h血清PCT、sTREM-1、hs-CRP水平差异,通过ROC曲线分析血清PCT、sTREM-1、hs-CRP预测NSCLC患者术后肺部感染的价值,以Logistic回归性分析PCT、sTREM-1、hs-CRP是否为NSCLC患者术后肺部感染的危险因素。【结果】肺部感染组血清PCT、sTREM-1、hs-CRP水平显著高于非肺部感染组,且差异有显著性(P<0.05)。经ROC分析PCT、sTREM-1、hs-CRP的下曲线面积分别为0.829、0.738、0.955。经Logistic回归性分析PCT>4.715、sTREM-1>4.410、hs-CRP>8.245是NSCLC患者术后肺部感染的危险因素。【结论】NSCLC术后肺部感染患者PCT、sTREM-1、hs-CRP水平呈高表达,是术后肺部感染的危险因素。

【Objective】To study the relationship between pulmonary infection and levels of procalcitonin(PCT),myeloid trigger receptor(sTREM-1)and hypersensitive C-reactive protein(hs-CRP)in patients with non-small cell lung cancer(NSCLC).【Methods】A total of 37 cases of NSCLC patients who received surgical treatment in our hospital and developed postoperative pulmonary infection were selected as the study subjects,and were set as the pulmonary infection group.In addition,37 cases of NSCLC patients who did not show postoperative pulmonary infection were set as the non-pulmonary infection group.Serum PCT,sTREM-1 and hs-CRP were detected in both groups after blood samples were collected 24h after surgery.ROC curve was used to analyze the value of serum PCT,sTREM-1 and hs-CRP in predicting postoperative pulmonary infection in NSCLC patients.Logistic regression was used to analyze whether PCT,sTREM-1 and hs-CRP were risk factors for postoperative pulmonary infection in NSCLC patients.【Results】The levels of PCT,sTREM-1 and hs-CRP in the lung infection group were significantly higher than those in the non pulmonary infection group(P<0.05).The lower curve areas of PCT,sTREM-1 and hs-CRP were 0.829,0.738 and 0.955 respectively by ROC analysis.Logistic regression analysis showed that PCT>4.715,sTREM-1>4.410,hs-CRP>8.245 were risk factors of postoperative pulmonary infection in NSCLC patients.【Conclusion】The high expression of PCT,sTREM-1 and hs-CRP in NSCLC patients with postoperative pulmonary infection is a risk factor of postoperative pulmonary infection.