新型冠状病毒感染导致脓毒症急性肺损伤的研究进展

The research progress of SARS-CoV-2 infection leading to acute lung injury induced by sepsis

自2019年12月以来,一种由冠状病毒家族新菌株严重急性呼吸综合征冠状病毒2(SARS-CoV-2)引起的急性呼吸道传染病迅速传播,目前正在全球范围内蔓延。新型冠状病毒肺炎(COVID-19)的发病机制可能是新型冠状病毒通过感染肺泡上皮细胞进而诱发细胞因子风暴导致的急性肺损伤(ALI),严重者可快速进展为急性呼吸窘迫综合征(ARDS)、感染性休克。早期进行治疗干预、免疫调节,或许有利于改善临床症状、延缓病情进展,从而降低病死率。本文综述SARS-CoV-2感染宿主细胞的病理生理机制,以期为COVID-19的预防和多靶点治疗提供研究方向。

Since December 2019,a new strain of the coronavirus family,severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)caused acute respiratory infectious diseases which spread quickly and became a pandemic,now is spreading worldwide.The pathogenesis of COVID-19 is a novel coronavirus infection in alveolar epithelial cells and induce cytokine storm which caused acute lung injury(ALI),severe cases can rapidly develop to acute respiratory distress syndrome(ARDS)and septic shock.Early treatment intervention and immune regulation may be helpful to improve the clinical symptoms,delay the progress of the disease,and reduce the mortality.This paper reviews the pathophysiology of SARS-CoV-2 infection in host cells aims to provide multiple targets for treatment and prevention of COVID-19.