毛药藤枝叶的化学成分研究

Chemical constituents of twigs and leaves of Sindechites henryi

目的:研究毛药藤枝叶中的化学成分.方法:采用硅胶、Sephadex LH-20、碳十八烷基反相键合硅胶(ODS)、制备高效液相(Pre-HPLC)等方法分离纯化,应用波谱学方法和理化性质鉴定化学结构.结果:从毛药藤枝叶的乙醇提取物中分离鉴定了16个化合物,分别为1-羟基-8-甲氧基蒽(1-hydroxy-8-methoxyanthraquinone,1)、大黄素(emodin,2)、大黄素甲醚(physcion,3)、曲霉酮8-O-β-D-吡喃葡糖糖苷(torachrysone 8-O-β-D-glucopyranoside,4)、黄杞苷(engeletin,5)、槲皮素3-O-α-L-鼠李糖苷(quercetin-3-O-α-L-rhamnopyranoside,6)、阿魏糖苷(ka-empferol 3-O-α-L-rhamnoside,7)、山奈酚-3-葡萄糖苷(kaempferol-3-glucoside,8)、扁蓄甙(avicularin,9)、槲皮素3-O-β-D-吡喃木糖苷(quercetin 3-O-β-D-xylopy-ranoside,10)、落新妇苷(astilbin,11)、番石榴苷(guaijaverin,12)、槲皮素(quercetin,13)、乔松酮(pinostrobin,14)、bistortaside A(15)、stigmast-4-en-6β-ol-3-one(16).结论:以上化合物均为首次从该植物中分离得到.

Objective:To study the chemical constituents of twigs and leaves of Sindechites henryi.Methods:The chemical constituents were isolated and purified by chromatography of silica gel,Sephadex LH-20 and octadecylsilica gel(ODS),and preparative HPLC.The structure was identified by spectroscopic methods and physicochemical properties.Results:Sixteen compounds were isolated and identified as 1-hydroxy-8-methoxyanthraquinone(1),emodin(2),physcion(3),torachrysone 8-O-β-D-glucopyranoside(4),engeletin(5),quercetin-3-O-α-L-rhamnopyranoside(6),kaempferol-3-O-α-L-rhamnoside(7),kaempferol-3-glucoside(8),avicularin(9),quercetin 3-O-β-D-xylopyranoside(10),astilbin(11),guaijaverin(12),quercetin(13),pinostrobin(14),bistortaside A(15),stigmast-4-en-6β-ol-3-one(16).Conclusion:All compounds were isolated from this plant for the first time.