摘要
设计了二苯并噻吩衍生物的合成与表征综合实验。实验主要包括:通过溴化反应、硼酸酯反应、Suzuki偶联反应、格式反应和关环反应合成二苯并噻吩衍生物,并运用核磁共振(NMR)技术(^1H NMR,^13C NMR,^1H-^1H COSY,HSQC,HMBC)研究其结构,且报道其波谱峰位的归属。通过该实验,学生可以比较完整、系统地了解有机合成的主要步骤与表征方法,并且通过分析NMR谱图,理解核磁共振技术在有机合成中确定未知物的重要作用。教学实践表明,该综合实验取得了较好的教学效果。
This paper aims to design a comprehensive chemical experiment of synthesis and characterization of dibenzothiophene derivatives.The experiment includes synthesis of new dibenzothiophene derivative,and the analysis of chemical structure by NMR(^1H NMR,^13C NMR,^1H-^1H COSY,HSQC,HMBC)techniques,and the NMR signals assignment of the 14,14-dimethyl-14 H-benzo[b]benzo[5,6]fluoreno[1,2-d]thiophene.Preparation and characterization of a new compound are one of the compulsory experimental courses for the materials science related field student.Consequently,the students can master the main steps and characterization methods of organic synthesis,and realize the important role of nuclear magnetic resonance technique in determining the structure of new compound.It is proven that the comprehensive experiment has achieved favorite results in practice teaching.
作者
郭婷
姚日晖
王丹
吴为敬
GUO Ting;YAO Rihui;WANG Dan;WU Weijing(School of Materials Science and Engineering,South China University of Technology,Guangzhou 510640,China)
出处
《实验室科学》
2020年第6期48-52,共5页
Laboratory Science
基金
国家自然科学基金(项目编号:21704027)
华南理工大学2018年本科实践教学改革项目(项目编号:Y9180640)。
关键词
综合实验
二苯并噻吩衍生物
实验教学
合成
comprehensive experiment
dibenzothiophene derivative
experimental teaching
synthesis
