口腔鳞癌Survivin表达的临床意义与PCNA关系研究

Clinical significance of survivin expression in OSCC and its correlation with PCNA

目的:探讨分析口腔鳞癌(Oral squamous cell carcinoma,OSCC)Survivin蛋白表达的临床意义和与其细胞增殖指标的相关性。方法:筛选106例OSCC肿瘤手术切除后标本,免疫组化方法检测Survivin蛋白和增殖细胞核抗原(Proliferating Cell Nuclear Antigen,PCNA)表达情况,SPSS17.0软件统计分析。结果:①74例(69.81%)OSCC组织表达Survivin,显著高于正常口腔黏膜组织(P<0.01)。PCNA标记指数(PCNA Label index,PLI)平均值为(55.01±22.02)%。②Survivin的表达与OSCC出现淋巴结转移及病理分级和TNM分期有明显相关性(P<0.01)。③Survivin与PCNA的表达明显相关(P<0.01)。结论:①Survivin蛋白表达量可做为一个OSCC预后效果的有效指标。②Survivin具有促进OSCC细胞增殖的作用。

Objective:To study investigate the clinical significance of survivin expression in oral squamous cell carcinoma(OSCC)and its correlation with proliferating cell nuclear antigen(PCNA).Methods:A total of 106 OSCC tumor specimens were screened out,and the expression of survivin protein and Proliferating Cell Nuclear Antigen(PCNA)was detected by immunohistochemical method.SPSS17.0 software statistical analysis was performed.Results:①Positive Survivin were detected in 74(69.81%)patients with OSCC,significantly higher than those in normal oral mucous group(P<0.01).PCNA labelling index(PLI)average value was(55.01±22.02)%.②The expression of survivin was closely related to the degree of tumor differentiation、lymph node metastasis and clinical stage(P<0.01).③There was a significant correlation between Survivin and PCNA expression(P<0.01).Conclusion:The expression of survivin is closely related to the clinicopathological characteristics of OSCC,which can be used as an effective index for the prognosis of OSCC.②Survivin can promote the proliferation of OSCC cells.