义齿基托抗菌物质抗真菌和细菌感染的研究进展

Advances in research on antifungal and antibacterial effect of removable dentures

义齿性口炎是戴用活动义齿患者口腔粘膜出现的一种常见的病理状态,常与口腔内真菌和细菌感染相关,有研究表明其主要致病原因为白色念珠菌感染。随着活动义齿上菌斑沉积量的增加,义齿性口炎发病率也增加且程度加重,二者呈正相关。为预防义齿性口炎,很多研究在活动义齿基托材料或基托软衬材料中加入抗真菌和抗细菌物质,包括纳米金属材料,碳基材料,植物或动物提取物,新型填充材料等。本文总结了这些常用的抗菌物质及其加入活动义齿基托类材料后的抗真菌和细菌感染的效果,如菌斑附着量的变化,材料的表面形态与力学性质等,发现这些物质加入基托材料后对白色念珠菌的生长均有抑制作用,但加入后活动义齿基托材料或基托软衬材料的物理、化学性能以及抗菌耐久性等是否符合临床使用的要求,需要进一步的实验验证。

Denture stomatitis is a common disorder affecting denture wearers.The main cause of the disease is candida albicans infection.With the increase of plaque deposition on removable denture,the incidence rate of denture stomatitis would increase,and the degree would aggravate,which was positively correlated.To prevent denture stomatitis,anti-fungal and anti-bacterial substances,such as nano-metal materials,carbon-based materials,plant or animal extracts,were added into removable denture base materials or soft-liner materials.This paper summarized the effect of commonly used anti-fungal and anti-bacterial substances and their influence on the mechanical properties of materials,which showed that base materials after adding these substances could inhibit the growth of candida albicans.However,whether the physical and chemical properties and antibacterial durability of the removeable denture base materials and soft-liner materials with these substances could meet the requirement of clinical use requires further experiment.