胸主动脉夹层动物模型研究进展

Research progress of animal models of thoracic aorta dissection

主动脉夹层(AD)是一种复杂且致死率高的疾病,特别是胸主动脉夹层(TAD),目前对AD的认知和治疗仍处于不断发展的阶段,理论与实践需要借助动物模型来完成转化,由此各种模型应运而生,互为补充、相互促进。要创建一个理想动物模型需先全面了解各种模型的利弊,才能取各家之长,达到自己的实验目的。TAD小动物模型主要通过化学诱导或转基因方式建模,TAD大动物模型则主要采用外科手术或腔内途径建模,笔者就以上TAD动物模型的各种建模方式作简要综述。

Aortic dissection(AD),especially the thoracic aortic dissection(TAD),is a complex and fatal disease.At present,the knowledge and treatment of AD are still under continuous development,and both theory and practice need to be developed by translational studies in animal models.As a result,various models have emerged,which are complementary and supplementary to each other.The creation of an ideal animal model firstly requires overall understanding of the advantages and limitations of each model,and then integrating the superiorities of each model,so as to achieve the purpose of the experiment.The small animal models of TAD are induced mainly by chemical induction or genetic modification,while the large-animal models of TAD are created mainly by surgical procedure or endovascular approach.Here,the authors present a brief overview on above modeling methods of the TAD animal models.