内消瘰疬丸联合碘^131治疗自主功能性甲状腺结节的疗效观察

Clinical observation of Neixiao Luoli Pills combined with iodide[131I]in treatment of autonomic functional thyroid nodules

目的探讨内消瘰疬丸联合碘^131治疗自主功能性甲状腺结节的临床疗效。方法选取2017年2月—2019年2月在驻马店市中心医院治疗的自主功能性甲状腺结节患者86例,采用随机数字表法分为对照组与治疗组(各43例)。对照组口服碘[131I]化钠口服溶液,555 MBq/次,1次/d。治疗组患者在给予服用碘[131I]化钠口服溶液同时口服内消瘰疬丸,1次8丸,3次/d。治疗4周对比效果。观察两组患者临床疗效,同时比较治疗前后两组患者甲状腺功能指标及甲状腺结节数目和大小。结果经治疗,治疗组有效率为97.67%,明显高于对照组(81.40%,P<0.05)。经治疗,2组三碘甲状腺原氨酸(T3)、甲状腺素(T4)、游离三碘甲状腺原氨酸(FT3)及游离甲状腺激素(FT4)水平均降低,而促甲状腺激素(TSH)水平均增高,且以治疗组改善显著(P<0.05)。经治疗,治疗组在甲状腺结节缩小及消失数目上均优于对照组(P<0.05)。结论内消瘰疬丸联合碘^131治疗自主功能性甲状腺结节可促进甲状腺结节的消失,改善机体甲状腺功能,具有一定的临床推广应用价值。

Objective To explore the clinical effect of Neixiao Luoli Pills combined with Iodide[131I]in treatment of autonomic functional thyroid nodules.Methods Patients(86 cases)with autonomic functional thyroid nodules in Zhumadian Central Hospital from February 2017 to February 2019 were randomly divided into control(43 cases)and treatment(43 cases)groups.Patients in the control group were po administered with Sodium Iodide[131I]Oral Solution,555 MBq/time,once daily.Patients in the treatment group were po administered with Neixiao Luoli Pills on the basis of the control group,8 pills/time,three times daily.Patients in two groups were treated for 4 weeks.After treatment,the clinical efficacy was evaluated,and the levels of T3,T4,TSH,FT3 and FT4,the number and size of thyroid nodules in two groups before and after treatment were compared.Results After treatment,the clinical efficacy in the control group was 81.40%,which was significantly lower than 97.67%in the treatment group,and there were differences between two groups(P<0.05).After treatment,the levels of T3,T4,FT3 and FT4 in two groups were significantly decreased(P<0.05),but the TSH levels in two groups were significantly increased(P<0.05),and the thyroid function in the treatment group was significantly better than that in the control group(P<0.05).After treatment,the number and size of thyroid nodules in the treatment group were significantly better than that in the control group(P<0.05).Conclusion Neixiao Luoli Pills combined with sodium iodide[131I]in treatment of autonomic functional thyroid nodules can promote the disappearance of thyroid nodules and improve the thyroid function,which has a certain clinical application value.