左氧氟沙星、利福平、多西环素三联治疗布鲁菌病患者的效果

Effects of triple therapy of Ofloxacin,Rifampicin and Doxycycline in treatment of patients with brucellosis

目的:观察左氧氟沙星、利福平、多西环素三联治疗布鲁菌病患者的效果。方法:选取60例布鲁菌病患者为研究对象,按照随机数字表法分为对照组32例与观察组28例。对照组给予利福平联合多西环素治疗,观察组在对照组基础上加用左氧氟沙星治疗,比较两组临床疗效、3个月复发率和不良反应发生率。结果:观察组治疗总有效率为92.86%,明显高于对照组的68.75%,差异有统计学意义(P<0.05);两组3个月复发率和不良反应发生率比较,差异无统计学意义(P>0.05)。结论:左氧氟沙星、利福平、多西环素三联治疗布鲁菌病患者可提高治疗总有效率,效果优于利福平联合多西环素治疗效果。

Objective:To explore effects of triple therapy of Ofloxacin,Rifampicin and Doxycycline in treatment of patients with brucellosis.Methods:60 patients with brucellosis were selected as the research objects,and were divided into control group(32 cases)and observation group(28 cases)according to the random number table method.The control group was treated with Rifampicin combined with Doxycycline,and the observation group was treated with Levofloxacin on the basis of those of the control group.The clinical efficacy,3-month recurrence rate and incidence of adverse reactions were compared between the two groups.Results:The total effective rate of treatment in the observation group was 92.86%,which was significantly higher than 68.75%in the control group,and the difference was statistically significant(P<0.05).However,there were no statistical differences in the 3-month recurrence rate and incidence of adverse reactions between the two groups(P>0.05).Conclusions:The triple therapy of Ofloxacin,Rifampicin and Doxycycline in the treatment of patients with brucellosis can improve the total effective rate of treatment.Moreover,it is superior to Rifampicin combined with Doxycycline.