磁纳米粒子介导的靶向剪切波弹性成像

Targeted shear wave elastography using magnetic nanoparticles

组织力学特性与其生理病理变化过程密切相关。因此,对组织力学特性的分析有望为疾病诊断提供重要依据。超声弹性成像可以定量分析组织的剪切模量,但在检测的特异性和灵敏度等方面仍存在局限性。针对这一问题,该文发展一种磁纳米粒子介导的靶向剪切波弹性成像新方法。该方法是基于磁纳米粒子在脉冲磁场作用下产生磁致振动,从而导致周围组织的剪切波传播,通过超声探测粒子振动及剪切波传播即可获得磁纳米粒子的分布及周围组织的弹性信息。基于该方法,该文在仿体水平实现对直径约3 mm的磁纳米粒子标记区域的振动检测及其周围组织的弹性信息获取。该研究有望为疾病的精准诊断提供新的思路。

Tissue mechanical properties are closely related to the process of physiological and pathological changes.Therefore,the analysis of shear modulus is expected to provide important information for disease diagnosis.Ultrasound elastography can quantitatively analyze the shear modulus of tissues,but there are still limitations in the specificity and sensitivity of detection.To solve this problem,we have developed the targeted shear wave elastography using magnetic nanoparticles.The method is mainly based on the magnetically induced vibration of magnetic nanoparticles under a pulsed magnetic field,leading to the shear wave propagation of surrounding tissues.Then,the distribution of magnetic nanoparticles and the elastic information of surrounding tissues can be detected by the collection information of particle vibration and shear wave propagation.Based on this method,the vibration detection of magnetic nanoparticles with a diameter of 3 mm and the elastic information acquisition of surrounding tissues of gel phantom are realized.This study is expected to provide new ideas for the accurate diagnosis of diseases.