无机纳米粒子/聚合物复合电纺纤维的制备及其仿生矿化研究

The preparation and biomimetic mineralization of inorganic nanoparticles/polymer composite nanofibers

静电纺丝技术能够利用简单的共混过程将无机纳米粒子和聚合物集于一根纳米纤维中并实现纳米粒子的快捷组装.由于这一特性,可将纳米粒子/聚合物复合电纺纤维应用于骨组织工程支架的构建中,模拟骨组织胶原分级有序结构,为骨修复提供一种新的思路.以聚乙烯醇和埃洛石为原料制备复合电纺纤维,并进行了仿生矿化.研究结果表明,埃洛石的加入可以提高聚乙烯醇纳米纤维的纺丝效果,但是也会随着浓度的增加,降低聚合物的结晶性能.并且,添加纳米粒子后,钙磷盐晶体能够在复合电纺纤维上定向析出,形成规则的矿化结晶物.由此可见,埃洛石纳米粒子对聚合物电纺纤维的仿生矿化具有一定促进作用,这对材料的细胞亲和性提高具有重要作用.

Electrospinning technology can integrate inorganic nanoparticles and polymers into a nanofiber by simple blending process and realize rapid assembly of nanoparticles.Because of this characteristic,nano-particle/polymer composite electrospinning fiber can be applied to the construction of bone tissue engineering scaffold,to simulate the collagen graded ordered structure of bone tissue and to provide a new idea for bone repair.Composite electrospun fibers were prepared from polyvinyl alcohol and halloysite,and the study of biomimetic mineralization was carried out.Results showed that the addition of halloysite could improve the spinning effect of PVA nanofibers,but it also decreased the crystallinity of the polymer with the increase of the concentration.In addition,after adding nanoparticles,calcium and phosphorus salt crystals could be sequentially precipitated on the composite electrospun fiber to form regular mineralized crystals.Therefore,the halloysite nanoparticles can promote the biomimetic mineralization of polymer electrospun fibers,which play an important role in improving the cell affinity of the materials.