角膜缘干细胞移植术的研究进展

Research progress on limbal stem cell transplantation

角膜缘干细胞缺乏(LSCD)是角膜缘干细胞数量减少或功能下降导致的角膜上皮细胞稳态失衡,以角膜上皮结膜化为特点的眼表疾病。保守治疗无效的重度LSCD患者常需行角膜缘干细胞移植术(LSCT)进一步治疗。本文就近年来开展的自体角膜缘移植(CLAU)、简化角膜缘上皮移植(SLET)、异体角膜缘移植、体外培养角膜缘干细胞移植(CLET)、体外培养口腔黏膜上皮细胞移植(COMET)5种手术治疗LSCD的研究进展进行综述,为临床提供数据基础。

Limbal Stem Cell Deficiency(LSCD)is an ocular surface disease caused by the decrease of the quantity and dysfunction of limbal stem cell,which is characterized by conjunctivalization and other signs of epithelial dysfunction.For sever LSCD,surgery is the main treatment way.Recently,plenty of researches published the outcomes of different operation methods.This article summarized five major operations,including conjunctival limbal autograft(CLAU),simple limbal epithelial transplantation(SLET),limbal allograft,cultivated limbal stem cell transplantation(CLET)and cultivated oral mucosal epithelial transplantation(COMET).