三项尿蛋白相关检测在肾小球疾病中的诊断价值

The diagnostic value of three-item urinary protein related tests for patients with glomerular disease

目的探讨24小时尿蛋白、肾病指数及尿蛋白肌酐比对肾小球疾病的诊断价值。方法选取四川大学华西医院收治的疑似肾小球疾病患者71例(观察组),同期健康体检者71例(对照组),检测24小时尿蛋白、肾病指数及尿蛋白肌酐比情况。结果观察组三项尿蛋白相关测定诊断的准确度、灵敏度、特异度比较,差异无统计学意义(P>0.05);观察组三项尿蛋白检测水平均高于对照组(P<0.05)。观察组24小时尿蛋白与尿蛋白肌酐比、肾病指数呈正相关(P<0.05)。结论三项尿蛋白相关测定均可完成对肾小球疾病患者病情的掌握程度,可根据患者实际情况选择适宜的检测方法,提升检测效率。

Objective To investigate the value of 24-hour urinary protein,nephrotic index and urinary protein creatinine ratio in the diagnosis of patients with glomerular disease.Methods Seventy-one patients with suspected glomerular disease in our hospital were randomly selected as observation group,and 71 people of healthy physical examination during the same period were selected as control group.The three-item urinary protein related tests were performed.Results There was no significant difference in accuracy,sensitivity and specificity among the three urinary protein related measurements in the observation group(P>0.05).The three urinary protein related measurements in the observation group were higher than those in the control group(P<0.05).A positive correlation was found between 24-hour urinary,protein urinary protein creatinine ratio and nephrotic index in the observation group(P<0.05).Conclusion All three urine protein related measurements can complete the mastery of the condition of patients with glomerular disease.Appropriate detection methods can be selected according to the actual situation of patients in order to improve the detection efficiency.