细菌GntR家族转录调控因子的研究进展

Progress on the GntR family transcription regulators in bacteria

GntR家族转录调控因子是细菌中分布最为广泛的一类螺旋–转角–螺旋(helix-turn-helix,HTH)转录调控因子,此家族转录调控因子包含两个功能域,分别是N端的DNA结合结构域和C端的效应物结合结构域/寡聚化作用结构域。DNA结合结构域的氨基酸序列是非常保守的,但效应物结合结构域/寡聚化作用结构域的氨基酸序列却存在很大的差异性。目前许多GntR家族的转录调控因子已经被鉴定,这些转录因子调控细菌许多不同的细胞过程,如运动性、葡萄糖代谢、细菌的耐药性、病原细菌的致病力等。本文主要阐述了GntR家族转录调控因子的发现、二级结构、生物学功能、调控模式等方面的研究进展,旨在为研究者全面、深入地了解GntR家族转录调控因子的功能及作用机理提供帮助。

In bacteria,GntR family transcription regulators are the widespread family of transcription factors.Members of this family consist of two functional domains,a conserved N-terminal DNA-binding domain that contains a typical helix-turn-helix(HTH)motif and a C-terminal effector-binding or oligomerization domain.Usually,the amino acid sequences of N-terminal DNA-binding domains are highly conserved,but differ in the C-terminal effector-binding or oligomerization domains.In the past several decades,many GntR family transcription regulators have been characterized in a number of bacteria.These regulators control a variety of cellular processes such as cell motility,glucose metabolism,bacterial resistance,pathogenesis and virulence.In this review,we summarized the discovery,C-terminal domains,biological function and regulation mode of GntR family transcription regulators.This review will help researchers to obtain more knowledge about the functions and mechanisms of the GntR family transcriptional regulatory factors.