针灸干预阿尔茨海默病代谢组学的研究进展

Research Progress of Acupuncture Intervention on Metabolomics of Alzheimer’s Disease

阿尔茨海默病是一种神经源性退行性病变,目前研究认为其早期诊断较可靠的生物标志物为Aβ蛋白及Tau蛋白,但仍无法以此确诊。代谢组学作为一种无创的且可非靶向检测技术,对本病血、尿等易采集且创伤小的标本中生物标志物的筛选起到较为重要的作用。针灸作为一种传统的保健及治疗方案,可通过干预脂质代谢、线粒体能量代谢及纠正氨基酸代谢紊乱状态调节脑内Aβ水平,改善相关症状,提高认知功能。本文对阿尔茨海默及轻度认知功能障碍的能量代谢、脂质代谢、氨基酸代谢及针灸的干预机制进行归纳整理,以期为本病的生物学标志物筛选及针灸治疗作用提供一些新的思路及方法。

Alzheimer’s disease is a neurogenic neurodegenerative disease.Current research believes that the more reliable biomarkers for early diagnosis are Aβprotein and Tau protein,but it is still unable to confirm this diagnosis.As a noninvasive and non-targetable detection technique,metabolomics has played a more important role in screening biomarkers in blood and urine samples that are easy to collect and less invasive.As a traditional health care and treatment plan,acupuncture can regulate Aβlevels in the brain by intervening in lipid metabolism,mitochondrial energy metabolism,and correcting amino acid metabolism disorders,improving related symptoms and improving cognitive function.This article summarizes the energy metabolism,lipid metabolism,amino acid metabolism,and acupuncture intervention mechanisms of Alzheimer and mild cognitive dysfunction,with a view to provide some new ideas for the screening of biological markers of this disease and the role of acupuncture treatment ideas and methods.