miRNA-自噬轴在运动性心肌肥大中的作用机制

Mechanism of MicroRNA-autophagy in Exercise Induced Cardiac Hypertrophy

心脏肥大是心脏受到生理或病理刺激而引起细胞和分子层面发生一系列变化的结果,运动性心肌肥大是心脏对长期运动产生的适应性变化。随着分子生物学相关研究的深入,运动性心肌肥大的形成不再认为仅仅是血流动力负荷所引起的细胞体积、结构和功能的改变。近年来的研究发现,miRNA和自噬被认为是调控运动性心肌肥大形成的重要因素。基于此,本文以心肌细胞自噬和miRNA为切入点,综述近年来运动诱导的心肌生理性肥大过程中自噬与miRNA发挥作用的机制,为进一步阐明运动性心肌肥大的机制提供依据。

Cardiac hypertrophy is the result of a series of cellular and molecular changes caused by physiological or pathological stimulation to the heart.Exercise-induced cardiac hypertrophy(ECH)is an adaptive change of the heart to the long-term exercise.However,with the development of molecular biology technology,the mechanisms of ECH is no longer considered as the change of cardiomyocytes volume,structure and function merely caused by hemodynamic load.Recent studies have found that miRNA and autophagy are important in regulating the formation of ECH.Therefore,this paper reviews the studies on the mechanism of autophagy and miRNA in exercise-induced cardiac hypertrophy in recent years,so as to provide reference for further clarifying the mechanism of exercise-induced cardiac hypertrophy.