药学干预对普外科围手术期质子泵抑制剂合理使用的效果评价

Evaluation of the Effect of Pharmaceutical Intervention on the Rational Use of Proton Pump Inhibitors(PPI)in the Perioperative Period of General Surgery

目的:探讨药学干预在普外科质子泵抑制剂合理用药方面的临床应用价值。方法:选取开封市中心医院普外科2019年3月-2020年4月手术患者共90例,按入院时间排序,奇数为对照组,偶数为观察组,每组各45例,对照组患者围手术期采用常规预防治疗。观察组在临床药师的指导下,结合质子泵抑制剂(PPI)使用诊疗指南、PPI使用剂量和持续时间,合理使用PPI。记录两组患者的所有临床信息。结果:对照组和观察组的一般临床资料比较差异无统计学意义(P>0.05),观察组在临床药师指导下合理使用PPI,观察组的使用PPI人数,PPI使用时间,PPI费用均明显低于对照组,两组比较差异有统计学意义(P<0.05)。结论:药学干预可以防止质子泵抑制剂在普外科围手术期患者身上的滥用,可以减少用药风险和节省患者费用,促进临床合理用药,具有临床推广价值。

Objective:To explore the clinical value of pharmaceutical intervention in the rational use of proton pump inhibitors in General Surgery.Methods:A total of 90 patients who underwent surgery in General Surgery Department in the hospital from March,2019 to April,2020 were selected.According to the time of admission,the odd number was in the control group,and the even number was in the observation group.There were 45 patients in each group.The patients in the control group were treated with routine preventive treatment during the perioperative period.The observation group were under the guidance of clinical pharmacists,combined with PPI diagnosis and treatment guidelines,PPI dosage and duration,rational use of PPI.All clinical information of patients in both groups was recorded.Results:There was no significant difference in the general clinical data between the observation group and the control group(P>0.05).Under the guidance of clinical pharmacists,the number of people using PPI,the time of using PPI and the cost of PPI in the observation group were significantly lower than those in the control group,and there was significant difference between the two groups(P<0.05).Conclusion:Pharmaceutical intervention can prevent the abuse of proton pump inhibitors in perioperative patients of general surgery,reduce the risk of drug use,save patients’expenses,and promote the rational use of drugs in clinic.