“清热祛湿解毒”治法系统性治疗慢性胃炎的机制分析

Mechanisms of Systematic Treatment of Chronic Gastritis by " Qingre Qushi Jiedu "Therapy

目的探究“清热祛湿解毒”治法系统性治疗慢性胃炎的机制。方法通过对中医药治疗幽门螺旋杆菌感染用药规律分析,该研究选取大黄、黄芩和黄连为治法的代表药物,通过成分靶点预测,与疾病靶点融合,筛选出核心靶点进行通路富集分析。结果通过网络药理学分析,MAPK3(ERK1)和MAPK2K1(MEK1)等靶点可能通过MAPK信号通路,ErbB等信号通路发挥重要作用。GO分析揭示细胞死亡和凋亡是最为重要的生物学过程。结论基于“清热祛湿解毒”治法的清热解毒药治疗慢性胃炎具有多成分、多靶点、多通路的特点。

Objective To explore the mechanism of"Qingre Qshi Jiedu"therapy in the treatment of chronic gastritis.Method-s Through the analysis of the rule of traditional Chinese medicine in the treatment of Helicobacter pylori infection,Rhei radix et rhizoma,Scutellariae radix and Coptidis rhizoma were selected as the representative drugs in this study.After predicting compo-nent targets and merging with disease related targets,core targets are screened for enrichment analysis.Results MAPK3(ERK1)and MAPK2K1(MEK1)may play an important role through the MAPK signaling pathway and ErbB signaling pathway through network pharmacological analysis.GO analysis revealed that cell death and apoptosis are the most important biological processes.Conclusion The Qingre Jiedu drugs based on qingre qvshi jiedu has the characteristics of multi-component,multi-target and multi-channel in the treatment of chronic gastritis.