摘要
核因子E2相关因子2(Nrf2)是一种细胞内转录调节因子,血红素加氧酶1(HO-1)是其最重要的下游调控产物之一,两者的级联反应在机体抗炎和抗氧化系统中十分关键。而促分裂原活化的蛋白激酶(MAPK)参与体内多种氧化应激和炎症反应过程并发挥重要调控作用。MAPK与Nrf2/HO-1信号通路间具有复杂的相互作用,且这一作用在不同的研究条件下并不一致。不同的MAPK可不同程度地影响Nrf2的活化,进而影响HO-1的表达;另外,HO-1降解胆红素的产物一氧化碳及其他Nrf2调控的基因也可能对一些MAPK具有调节作用。同时,细胞内其他信号分子的影响进一步增加了MAPK与Nrf2/HO-1信号通路相互作用的多样性。
Nuclear factor-erythroid 2-related factor 2(Nrf2)is an intracellular transcriptional regulator and Heme oxygenase-1(HO-1)is one of its most important downstream regulatory products.The cascade reaction of the two is critical in the body′s anti-inflammatory and antioxidant systems.Mitogen-activated protein kinases(MAPK)are involved in various processes of oxidative stress and inflammatory response in vivo and play an important regulatory role.There is a complex interaction between MAPK and Nrf2/HO-1 signaling pathway,which is inconsistent under different conditions of researches.Different MAPK can affect the activation of Nrf2 and thus affect the expression of HO-1.Carbon monoxide,one of the products of bilirubin degraded by HO-1 and other Nrf2 regulated genes may also have regulatory effects on some MAPK.In addition,the influence of other signaling molecules within the cell further increases the diversity of their interactions.
作者
李彦霖
郁叶
郭婷莉
易鑫尧
张萌
陈莉娜
LI Yanlin;YU Ye;GUO Tingli;YI Xinyao;ZHANG Meng;CHEN Lina(The First School of Clinical Medicine,Xi′an Jiaotong University,Xi′an 710061,China;School of Basic Medical Science,Xi′an Jiaotong University,Xi′an 710061,China)
出处
《医学综述》
2021年第1期8-13,共6页
Medical Recapitulate
基金
国家自然科学基金(81471031)。
