基于针刺介导的内脏运动神经抗炎机制研究

Study on Anti-inflammatory Mechanism of Acupuncture-mediated Visceral Motor Nerve

针灸在我国临床上的应用由来已久,针灸具有的抗炎功效得到了临床医师及患者的一致认可,关于其抗炎机制也逐渐受到相关研究人员的关注。胆碱能抗炎通路(CAP)是一条以迷走神经、乙酰胆碱及特异性乙酰胆碱受体为基础的神经-免疫调节通路,采用针刺疗法刺激交感神经系统能够激活CAP。目前,关于针刺如何通过介导交感神经激活CAP发挥其抗炎作用虽然已有大量实验结果和文献研究进行阐述,但仍未形成系统的理论体系。

Acupuncture and moxibustion has been used for a long time in China′s clinical practice.Its anti-inflammatory effect has been unanimously recognized by the clinicians and patients,and the research on its anti-inflammatory mechanism has gradually attracted the attention of relevant researchers.Cholinergic anti-inflammatory pathway(CAP)is a neuroimmunomodulatory pathway based on vagus nerve,acetylcholine and specific acetylcholine receptor.Previous studies have shown that stimulation of sympathetic nervous system by acupuncture can activate CAP.Although there are a lot of experimental results and literature studies on how acupuncture can activate CAP to play its anti-inflammatory role through mediating sympathetic nerve,there is still no systematic theoretical system established.