糖尿病大血管病变多组学研究进展

Research Progress in Multi-omics of Diabetic Macroangiopathy

糖尿病血管病变作为糖尿病进展、全身多器官损伤和心脑血管疾病发生的基础原因之一,具有很强的破坏性,是糖尿病的主要并发症及死亡原因。糖尿病血管病变是多基因、多蛋白共同参与的一种全身系统性代谢性疾病,在基因组学、转录组学、蛋白质组学以及代谢组学层面均有特异性的表现特征。随着高通量组学检测技术的快速发展,可利用不同组学技术从不同层面探究糖尿病大血管病变的发生发展机制,也可通过联合分析各组学数据促进各组学互通,这为阐明糖尿病大血管病变的分子发病发展机制提供了新的研究思路。

Diabetic angiopathy,as one of the basic causes of diabetic progression,multiple-organ injury and cardio-cerebrovascular disease,is highly destructive.Diabetic angiopathy is a major complication and leading cause of death in diabetes.Diabetic angiopathy is a systemic metabolic disease with the participation of multiple genes and proteins,which has specific characteristics at the genomics,transcriptomics,proteomics and metabonomics levels.With the rapid development of high-throughput sequencing and detection technology,different omics techniques can explore the occurrence and development mechanism of diabetic macroangiopathy from different omics levels,and the different omics data can also be communicated through joint analysis,which provides a new direction to elucidate the molecular pathogenesis of diabetic macroangiopathy.