培菲康预防盆腔恶性肿瘤术后放疗急性放射性肠炎的临床观察

Clinical observation on the prevention of acute radiation enteritis after radiotherapy for pelvic malignant tumor by bifidobacterium triplex active bacterium preparation(Peifikang)

目的:探讨双歧杆菌三联活菌制剂(培菲康)预防盆腔恶性肿瘤术后放疗急性放射性肠炎的临床效果。方法:回顾性收集2018年6月—2019年6月本院接收的盆腔恶性肿瘤术后放疗患者60例,将采用放疗+/-同期化疗治疗的30例患者研究资料纳入对照组,将采用放疗+/-同期化疗联合培菲康治疗的30例患者研究资料纳入观察组。出现放射性肠炎后两组均按常规处理(生理盐水+地塞米松+维生素B12+普鲁卡因+康复新液保留灌肠)。观察两组患者急性放射性肠炎发生时间、持续时间、放射性肠炎分级以及T辅助细胞(CD4)、T杀伤细胞(CD8)、CD4/CD8值。结果:与对照组比较,观察组急性放射性肠炎发生时间较晚,持续时间较短,差异有统计学意义(P<0.05);放疗后,观察组放射性肠炎发生率低于对照组,差异有统计学意义(P<0.05);两组治疗前CD4、CD8及CD4/CD8值比较,差异无统计学意义(P>0.05),放疗后,两组CD4、CD8及CD4/CD8值较放疗前高,且观察组较对照组高,差异有统计学意义(P<0.05)。结论:接受放射治疗的盆腔恶性肿瘤患者运用双歧杆菌三联活菌制剂可降低放射性肠炎发生率,缩短放射性肠炎持续时间,促进免疫功能恢复,值得临床推广应用。

Objective:To investigate the clinical effect of bifidobacterium triple active preparation(Pefeikang)in preventing acute radiation enteritis after radiotherapy for pelvic malignant tumor.Methods:A total of 60 patients with pelvic malignancies who received postoperative radiotherapy in the First Department of Radiotherapy of Ganzhou Cancer Hospital from June 2018 to June 2019 were retrospectively collected.The study data of 30 patients treated with radiotherapy+/-concurrent chemotherapy were included in the control group,and the data of 30 patients treated with radiotherapy+/-concurrent chemothera py combined with Peifikang(bifidobacterium triple living bacterium preparation)were included in the observation group.After the occurrence of radiation enteritis,both groups were treated with routine treatment(normal saline+dexamethasone+vitamin B12+procaine+rehabilitation solution retention enema).The occurrence time,duration,grade of radioactive enteritis,T helper cells(CD4),T killer cells(CD8),and CD4/CD8 values were observed in both groups.Results:Compared with the control group,acute radiation enteritis in the observation group occurred later and lasted shorter,and the difference was statistically significant(P<0.05).After radiotherapy,the incidence of radiation enteritis in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).The CD4,CD8,and CD4/CD8 values of the two groups before the treatment were not statistically different(P>0.05).After radiotherapy,the CD4,CD8,and CD4/CD8 values were higher than those before radiotherapy,and the observation group was significantly higher than the control group(P<0.05).Conclusion:The application of Bifidobacterium triple viable preparations for patients with pelvic malignant tumors receiving radiotherapy can reduce the incidence and shorten the duration of radiation enteritis,and can promote the recovery of immune functions.It is worthy of clinical application.