阿立哌唑联合碳酸锂治疗缓解期双相障碍临床疗效及对患者认知功能的影响

Efficacy of Aripiprazole Combined with Lithium Carbonate in the Treatment of Patients with Bipolar Disorder During Remission Period and Its Effect on Cognitive Function

目的探讨阿立哌唑联合碳酸锂治疗缓解期双相障碍的临床疗效及对患者认知功能的影响。方法选取医院2017年9月至2019年9月收治的双相障碍缓解期患者92例,随机分为观察组和对照组,各46例。对照组患者给予碳酸锂治疗,观察组患者在此基础上加用阿立哌唑治疗。两组患者均连续治疗3个月。结果观察组总有效率为89.13%,明显高于对照组的71.74%(P<0.05);治疗后,观察组患者的阳性与阴性症状量表(PANSS)评分中阳性症状、阴性症状、一般精神病理症状、总分均低于对照组(P<0.05);观察组患者的韦克斯勒记忆量表(WMS)、个人与社会功能量表(PSP)评分均高于对照组(P<0.05);观察组患者的生理健康、心理健康、社会关系和周围环境评分均高于对照组(P<0.05);观察组与对照组不良反应发生率相当(17.39%比10.87%,P>0.05)。结论阿立哌唑联合碳酸锂治疗缓解期双相障碍疗效显著,能进一步降低患者的症状评分,提高认知功能,改善生活质量,且安全性良好。

Objective To investigate the clinical efficacy of aripiprazole combined with lithium carbonate in the treatment of patients with bipolar disorder during remission period and its effect on cognitive function.Methods Totally 92 patients with bipolar disorder during remission period admitted to our hospital from September 2017 to September 2019 were selected and randomly divided into the observation group and the control group,46 cases in each group.The patients in the control group were treated with lithium carbonate,on this basis,the patients in the observation group were treated with aripiprazole.Both groups were continuously treated for 3 months.Results The total effective rate of the observation group was 89.13%,which was significantly higher than 71.74%of the control group(P<0.05).After treatment,the scores of total Positive and Negative Symptoms Scale(PANSS),PANSS P(positive scale),PANSS N(negative scale)and PANSS G(general psychopathology scale)in the observation group were lower than those in the control group(P<0.05).The scores of Wechsler Memory Scale(WMS)and Personal and Social Performance Scale(PSP)in the observation group were higher than those in the control group(P<0.05).The scores of physical health,mental health,social relations and surrounding environment in the observation group were higher than those in the control group(P<0.05).The incidence of adverse reactions in the observation group was similar to that in the control group(17.39%vs.10.87%,P>0.05).Conclusion Aripiprazole combined with lithium carbonate is effective and safe in the treatment of patients with bipolar disorder during remission period,which can further reduce the symptom score,improve cognitive function and the quality of life.