摘要
目的建立测定西瓜霜润喉片中西瓜霜含量的离子色谱法。方法采用Dionex IonPac^TM CS12A阳离子交换色谱柱(250 mm×4 mm),Dionex CERS 500型抑制器(规格为4 mm),淋洗液为15 mmol/mL甲磺酸溶液,流速为1.0 mL/min,进样量为10μL,电导检测器进行检测,西瓜霜的含量以硫酸钠计。结果硫酸钠进样量在0.9990~99.8996μg/mL范围内线性关系良好(r=1.0000);平均加样回收率为100.10%,RSD为2.03%(n=9)。结论离子色谱法专属性强,操作简便,结果准确,可用于西瓜霜润喉片中西瓜霜的含量测定。
Objective To establish an ion chromatography method for content determination of watermelon frost in Watermelon Frost Runhou Tablets.Methods The Dionex IonPacTMCS12A cation exchange chromatographic column(250 mm×4 mm)and Dionex CERS 500 suppressor(4 mm)were eluted with 15 mmol/mL of methanesulfonic acid solution at the flow rate of 1.0 mL/min,and the injection volume was 10μL.The conductivity detector was used for detection,and the content of watermelon frost was calculated by sodium sulfate.Results The linear range of sodium sulfate was 0.9990-99.8996μg/mL(r=1.0000).The average recovery was 100.10%,and the RSD was 2.03%(n=9).Conclusion This method is specific,simple and accurate,which can be used for the content determination of watermelon frost in Watermelon Frost Runhou Tablets.
作者
唐燏峰
彭飞燕
唐蕾
罗亚虹
王许飞
马强薇
TANG Yufeng;PENG Feiyan;TANG Lei;LUO Yahong;WANG Xufei;MA Qiangwei(Guilin Institute for Food and Drug Control,Guilin,Guangxi,China 541001;Guilin Sanjin Pharmaceutical Co.,Ltd.,Guilin,Guangxi,China 541004)
出处
《中国药业》
CAS
2021年第1期67-69,共3页
China Pharmaceuticals
基金
广西壮族自治区食品药品监督管理局2016年食品药品安全科研项目[桂食药监科评〔2016〕8号]。
关键词
离子色谱法
西瓜霜润喉片
西瓜霜
硫酸钠
含量测定
ion chromatography
Watermelon Frost Runhou Tablets
watermelon frost
sodium sulfate
content determination