硫唑嘌呤致克罗恩病患者白细胞减少药学监护实践

Pharmaceutical Care of Azathioprine-Induced Leukopenia in a Patient with Crohn’s Disease

目的探讨临床药师在硫唑嘌呤致药源性白细胞减少症个体化治疗和用药监护中的作用。方法临床药师参与1例克罗恩病患者服用硫唑嘌呤后致白细胞减少的药学监护实践,判断可疑药物与该不良反应间的关系,协助临床医师调整药物治疗方案。结果临床药师及时评估与处理药品不良反应,并根据基因多态性检测和病情变化协助医师调整用药方案,提供个体化药学服务,提高治疗依从性和临床疗效。结论临床药师实施恰当的药学监护,有助于建立个体化治疗方案,促进临床用药的有效性及安全性。

Objective To investigate the role of clinical pharmacists in individualized treatment and pharmaceutical care of azathioprine-induced leukopenia(AIL).Methods The clinical pharmacist participated in the pharmaceutical care of AIL in a patient with Crohn’s disease,judged the correlation between the suspicious drug and the adverse reaction,and assisted the clinician to adjust the medication plan.Results Clinical pharmacists could evaluate and deal with adverse drug reactions in time,and assist clinician to adjust the medication plan according to the detection of gene polymorphism and the changes of disease condition,provide individualized pharmaceutical care,and improve treatment compliance and clinical efficacy.Conclusion The implementation of appropriate pharmaceutical care by clinical pharmacists is helpful to establish an individualized treatment plan and promote the effectiveness and safety of the clinical medication.