摘要
以8-氮杂螺[4.5]癸烷-7,9-二酮为原料,通过酰胺还原、N-Boc保护、甲酰化、醛基四步反应还原反应合成得到目标化合物7-(羟甲基)-8-氮杂螺[4.5]癸烷-8-羧酸叔丁酯,总收率29.8%。反应中间体及产物结构经1H NMR和ESI-MS确证,同时对每步反应条件进行讨论。该研究提供了一种新结构的含氮螺环化合物的合成路线。
Methyl 7-(hydroxymethyl)-8-azaspiro[4.5]decane-8-carboxylate was synthesizedby using8-azaspiro[4.5]decane-7,9-dione as starting material with four-step reactioninvolving amide reduction,N-Boc protection,formylation reaction and aldehyde group reduction and a total yield of 29.8%was obtained.The structure of intermediates and the product were confirmed by 1H NMR and ESI-MS.Apractical route for the novel nitrogen containing spirocyclic compound was provided in this work.
作者
王艳娇
梁雪
徐小娜
刘斌
WANG Yan-jiao;LIANG Xue;XU Xiao-na;LIU Bin(Collaborative Innovation Center of Green Manufacturing Technology for Traditional Chinese Medicine in Shaanxi Province,School of Pharmacy,Shaanxi Institute of International Trade&Commerce,Xi’an 712046,China;School of pharmaceutical&Chemical Engineering,Xianyang Vocational Technical College,Xianyang 712000,China)
出处
《化学研究与应用》
CAS
CSCD
北大核心
2021年第1期103-107,共5页
Chemical Research and Application
基金
陕西省自然科学基础研究计划(面上)项目(2018JM7046)资助
陕西省中药绿色制造技术协同创新中心重点培育项目(2019XT-1-05)资助
陕西省中药绿色制造技术协同创新中心一般培育项目(2019XT-3-09)资助
陕西国际商贸学院2020年科学研究项目(SMXY202018)资助。
关键词
含氮杂环
螺环化合物
Boc-保护基
合成
nitrogen heterocyclic ring
spirocyclic compound
Boc-protecting group
synthesis
