Ni(PPh 3)2Cl2催化2-氯嘧啶与芳基硼酸的Suzuki-Miyaura偶联反应

Nickel-catalyzed Suzuki-Miyaura coupling reaction of 2-chloro pyrimidines with aryl boronic acid

本文在Ni(PPh 3)2Cl 2催化下顺利实现了不同取代基2-氯嘧啶与芳基硼酸的Suzuki-Miyaura偶联反应。实验表明,取代基的电子效应和空间位阻效应对2-氯嘧啶的反应活性影响较小。该反应产率良好,官能团耐受性好,为2-芳基嘧啶衍生物的合成提供了一类简单有效的方法。

The Ni(PPh 3)2Cl 2 catalyzed Suzuki-Miyaura coupling reaction of various 2-chloro pyrimidines with aryl boronic acids was successfully achieved.The experimental results showed that the electronic and steric hindrance effect of substituents had little effect on the reactivity of 2-chloro pyrimidines.This reaction provided a simple and effective way for the synthesis of 2-aryl pyrimidine derivatives because of its excellent yield and functional group tolerance.