2-氰基-4’-甲基联苯的合成

Synthesis of 2-cyano-4′-methylbiphenyil

以对氯甲苯(PCT)和金属镁为原料,碘引发剂下进行Grignard反应制备对甲基苯基氯化镁,然后与邻氯苯腈(OCBN)在过渡金属化合物催化不对称偶联反应制备2-氰基-4′-甲基联苯(OTBN)。结果表明:以过渡金属MnCl 2为催化剂,四氢呋喃(THF)和2-甲基四氢呋喃(MeTHF)混合溶剂下,可有效调控不对称偶联反应中产物的分布和区域选择。该合成路线具有催化效果好、溶剂回收率高、环境友好、成本低廉、操作简便等特点,易于实现工业化生产。

p-Methylphenylmagnesium chloride was synthesized by Grignard reaction under iodine initiator,p-chlorotoluene(PCT)and metal magnesium using as raw materials,then 2-cyano-4′-methylbiphenyl(OTBN)was prepared by asymmetric coupling reaction with o-chlorobenzonitrile(OCBN),transition metal compound over catalyst.The results showed that the product distribution and region selection in asymmetric coupling reaction could be effectively controlled by using transition metal MnCl 2 as catalyst,and under conditions of mixed solvent of tetrahydrofuran(THF)and 2-methyltetrahydrofuran(MeTHF).The synthesis route had significant advantages,including good catalytic effect,high solvent recovery,friendly environmental,low cost and simple operation,which was convenient for industrialization.