粪菌移植治疗中枢神经系统疾病的研究进展

Research advances in fecal microbiota transplantation for the treatment of central nervous system disorders

中枢神经系统疾病除了神经系统相关症状外,常伴随胃肠道症状,在不同疾病患者体内可观察到相应肠道菌群失调现象。肠道菌群及代谢产物可通过外周神经、免疫等途径参与中枢神经系统活动,肠道菌群失调与阿尔兹海默病、帕金森病、肌萎缩性脊髓侧索硬化、多发性硬化等多种中枢神经系统疾病的发生发展密切相关,有研究证明,模型动物或患者在接受粪菌移植治疗后症状改善。该文就粪菌移植治疗中枢神经系统疾病中的研究进展进行综述。

Central nervous system(CNS)disorders usually have gastrointestinal dysfunction beyond CNS symptoms,and gut microbiota dysbiosis can be found in patients with various CNS diseases.Intestinal microbiota and its metabolic products can participate in the activity of the central nervous system through peripheral nerves and immune pathways.Gut microbiota dysbiosis is closely associated with the development and progression of several CNS diseases such as Alzheimer’s disease,Parkinson’s disease,amyotrophic lateral sclerosis,and multiple sclerosis.It has been reported that model animals or patients benefit from fecal microbiota transplantation(FMT).This paper reviews the research progress in FMT for CNS diseases.