双酚A雌性生殖毒性及其机制研究进展

Advances in the study of female reproductive toxicity of bisphenol A and its mechanism

双酚A(bisphenol A,BPA)作为一种重要的有机化工原料,广泛用于生产高分子材料及精细化工产品,属于环境内分泌干扰物。BPA可以通过消化道、呼吸道以及皮肤进入机体,对多个系统均能产生有害的影响,其生殖系统毒性尤为引起人们重视。流行病学调查结果与动物实验数据表明,BPA暴露对雌性生殖系统会产生不利的影响,但具体机制尚不十分明确。本文综述了BPA对雌性生殖系统的影响及其相关机制。

Bisphenol A(BPA),as an important organic chemical material,is widely used in the production of polymer materials and fine chemical products.BPA,an environmental endocrine disruptor,enters the body through the digestive tract,respiratory tract and skin and can have adverse effects on multiple organ systems,especially the reproductive system.Epidemiologic findings and animal data indicate that BPA exposure has an adverse effect on the female reproductive system,but the mechanism is still not clear.This article reviews the effects of BPA on the female reproductive system and the related mechanisms.