摘要
目的:观察3种常用抗精神分裂药物(利培酮、奥氮平、喹硫平)给药后的血药浓度情况,探讨血药浓度的影响因素和浓度/剂量(C/D)比值在不同人群中的差异,为药物的个体化治疗提供参考。方法:采用回顾性研究方法,分析本中心在2019年6月–2020年2月期间住院的712例精神分裂症患者的血药浓度监测数据,参照相关指南推荐的标准确定血药浓度参考范围,并计算浓度/剂量(C/D)比值。结果:给予利培酮、奥氮平和喹硫平治疗的患者处在参考浓度范围内的比例分别为70.0%,70.6%和68.6%;低剂量水平的C/D比值显著高于高剂量水平;女性患者C/D比值高于男性;60岁以上患者C/D比值高于年轻患者。结论:本中心三种药物的临床给药剂量基本合理,女性和老年患者建议适当减少给药剂量以避免不良反应的发生。
Objective:To investigate the blood concentration of three common antipsychotic drugs(risperidone,olanzapine,quetiapine)after administration,explore the influence factors of blood concentration and the difference of concentration/dose(C/D)ratio in different populations,so as to provide references for the individualized medication.Methods:Therapeutic drug monitoring(TDM)data of 712 schizophrenic inpatients in a center from June 2019 to February 2020 were retrospectively analyzed.The reference range of blood concentration of the three antipsychotic drugs was determined according to the related guideline and the C/D ratio was calculated.Results:The proportions of patients treated with risperidone,olanzapine and quetiapine whose blood concentrations of the three drugs were within the reference concentration range were 70.0%,70.6%and 68.6%,respectively.The C/D ratio of low-dose level was significantly higher than that of high-dose level.The C/D ratio of female patients was higher than that of male patients.The C/D ratio of patients over 60 years old was higher than that of patients below 60 years old.Conclusion:The clinical dosage of the three drugs was generally reasonable.Female and elderly patients should reduce the dosage in order to avoid the occurrence of the adverse drug reactions.
作者
陈春武
栾燕
王曾晖
苗彦明
王爽
CHEN Chun-wu;LUAN Yan;WANG Zeng-hui;MIAO Yan-ming;WANG Shuang(Department of Psychology,Shenyang Mental Health Center,Shenyang 110168,China;Dalian Runsheng Kangtai Medical Laboratory Limited Company,Dalian 116033,China)
出处
《中国药物应用与监测》
CAS
2020年第6期360-363,共4页
Chinese Journal of Drug Application and Monitoring
关键词
精神分裂
治疗药物监测
血药浓度
分析
Schizophrenia
Therapeutic drug monitoring
Blood drug concentration
Analysis