坏死性凋亡及其相关疾病的研究进展

Research progress of necroptosis and related diseases

坏死性凋亡,即程序性坏死,主要由细胞因子(TNF-α、IFN-α、IFN-γ)、Toll样受体(TLR3、TLR4、TLR9)以及核酸(DNA、RNA)感受器等介导起始过程。受体相互作用蛋白激酶1(RIPK1)、受体相互作用蛋白激酶3(RIPK3)和底物混合谱系激酶样蛋白(MLKL)参与坏死性凋亡的发生,MLKL是关键分子。目前研究发现,坏死性凋亡与感染性疾病、神经系统疾病、炎症、癌症的发生密切相关。本文将对细胞坏死性凋亡在炎性因子失衡中的作用、坏死性凋亡发生的分子机制、坏死性凋亡与多种疾病的关系以及治疗药物研究进展方面进行综述。

Necroptosis is programmed death,and is mainly caused by cytokines(TNF-α,IFN-α,IFN-γ),Toll-like receptors(TLR3,TLR4,TLR9)and nucleic acid(DNA,RNA)sensors.Receptor interacting serine/threonine protein kinase 1(RIPK1),receptor interacting serine/threonine protein kinase 3(RIPK3)and mixed lineage kinase domain like pseudokinase(MLKL)are involved,and MLKL is the key molecule.The current research found that necroptosis has been linked to infectious diseases,neurological diseases,inflammatory diseases and cancer.In this article,the role of necroptosis will be reviewed in the imbalance of inflammatory cytokines,the molecular mechanism,the correlation between necroptosis and a variety of diseases and therapeutic drugs.