康莱特注射液用于中晚期肺癌治疗的联合用药研究

Combined Medication of Kanglaite Injection in the Treatment of Advanced Lung Cancer

目的:探讨康莱特注射液在肺癌治疗过程中联合用药的合理性,为临床用药提供参考。方法:采用回顾性研究方法,通过医院信息系统,选取2018年北京中医药大学东方医院所有使用康莱特注射液的肺癌患者信息,利用Clementine 12.0、SPSS 19.0及Excel 2010等统计软件,结合药品说明书,分析康莱特注射液在肺癌治疗过程中联合用药的合理性。结果:共收集到150份独立病历中(涉及96例患者),治疗方案主要包括姑息治疗(105份,占70.0%)、化疗(17份,占11.3%)、靶向治疗(16份,占10.7%)及氩氦刀手术治疗(14份,占9.3%,其中2份同时进行化疗)。联合用药频率排序居前10位的药品为盐酸氨溴索注射液、多索茶碱注射液、肝素钠注射液、盐酸甲氧氯普胺注射液、消癌平注射液、氯化钾注射液、榄香烯注射液、呋塞米注射液、人血白蛋白和艾迪注射液,其中有3种为抗肿瘤中药注射剂。分析联合用药规则,化疗患者中使用康莱特注射液与止吐药、抗过敏药和抗肿瘤中药注射剂的关联强度较大,姑息治疗患者中使用康莱特注射液与化痰平喘药、营养补充剂的关联强度最大。结论:康莱特注射液在不同肺癌治疗方案中均有较为广泛的临床应用,与康莱特注射液联合应用的药品大部分为预防用药。

OBJECTIVE:To probe into the rationality of combined medication of kanglaite injection in the treatment of advanced lung cancer,so as to provide reference for clinical medication.METHODS:Retrospective study was conducted to extract the information of all lung cancer patients who received kangwright injection in Dongfang Hospital,Beijing University of Chinese Medicine in 2018 through the hospital information system.Combined with drug instructions,Clementine12.0,SPSS 19.0,Excel 2010 and other statistical software were used to analyze the rationality of combined medication of kanglaite injection in the treatment of lung cancer.RESULTS:Of the 150 independent medical records(96 patients),the treatment regimens were mainly palliative treatment(105 medical records,70.0%),chemotherapy(17 medical records,11.3%),targeted therapy(16 medical records,10.7%)and argon-helium surgery(14 medical records,9.3%,including 2 medical records receiving concurrent chemotherapy).The top 10 drugs with the highest frequency of drug combination were ambroxol hydrochloride injection,doxofylline injection,heparin sodium injection,metoclopramide hydrochloride injection,Xiao’aiping injection,potassium chloride injection,elemene injection,furosemide injection,human albumin and aidi injection,of which 3 were antitumor traditional Chinese medicine injections.Analysis of combined medication rules showed that in patients with chemotherapy,the correlation between kanglaite injection and antiemetic,antiallergic and anti-tumor traditional Chinese medicine injections was relatively strong,while in patients with palliative treatment,the correlation between drugs for resolving sputum and relieving asthma and nutritional supplements was the strongest.CONCLUSIONS:Kanglaite injection has a wide range of clinical application in different lung cancer treatment regimens,and most of the drugs used in combination with kanglaite injection are preventive drugs.