CSE/H2S通路对心肌缺血再灌注损伤保护作用的研究进展

Research Advances in the Protective Effect of CSE/H2S Pathway on Myocardial Ischemia Reperfusion Injury

再灌注是急性心肌梗死常用的治疗措施,但再灌注常导致心肌舒缩功能障碍、心肌细胞不可逆损伤加重等并发症,引起心肌缺血再灌注损伤(myocardial ischemia reperfusion injury,MIRI)。胱硫醚-γ-裂解酶(cystathionine-γ-lyase,CSE)/硫化氢(hydrogen sulfide,H2S)通路在MIRI发生发展中起关键保护作用,其机制包括保护线粒体、抗氧化应激、调节内皮一氧化氮合酶活性等多方面,故本文从CSE/H2S产生的调节因素,对MIRI的保护机制及中西医临床应用的最新研究进展作一阐述。

Reperfusion is a common treatment in acute myocardial infarction.However,reperfusion can cause myocardial systolic and diastolic dysfunction,and aggravate irreversible damage to myocardial cells and other complications,cause myocardial ischemia reperfusion injury(MIRI).The cystathionine-γ-lyase(CSE)/hydrogen sulfide(H2S)pathway plays an important role in the occurrence and development of MIRI,with protective effects including protection of mitochondria,anti-oxidative stress,regulation of endothelial nitric oxide synthase activity.This paper will review the research advances of the regulatory factors for CSE/H2S production,the protective mechanism of MIRI,and the clinical application.